Dimethylformamide

About Dimethylformamide

The primary use of DMF is as a solvent with low evaporation rate. DMF is used in the production of acrylic fibers and plastics. It is also used as a solvent in peptide coupling for pharmaceuticals, in the development and production of pesticides, and in the manufacture of adhesives, synthetic leathers, fibers, films, and surface coatings.^[6]

• It is used as a reagent in the Bouveault aldehyde synthesis^[17][18][19] and in the Vilsmeier-Haack reaction,^[11][12] another useful method of forming aldehydes.
• It is a common solvent in the Heck reaction.^[20]
• It is also a common catalyst used in the synthesis of acyl halides, in particular the synthesis of acyl chlorides from carboxylic acids using oxalylor thionyl chloride. The catalytic mechanism entails reversible formation of an imidoyl chloride.^[21][22]
• DMF penetrates most plastics and makes them swell. Because of this property DMF is suitable for solid phase peptide synthesis and as a component of paint strippers.
• DMF is used as a solvent to recover olefins such as 1,3-butadiene via extractive distillation.
• It is also used in the manufacturing of solvent dyes as an important raw material. It is consumed during reaction.
• Pure acetylene gas cannot be compressed and stored without the danger of explosion. Industrial acetylene is safely compressed in the presence of dimethylformamide, which forms a safe, concentrated solution. The casing is also filled with agamassan, which renders it safe to transport and use.